MacMillan催化剂水相不对称催化Aldol反应

MacMillan Catalyst for the Asymmetric Aldol Reactions in Water

以自制的手性MacMillan催化剂MM3-2与1当量HCl,在水相中不对称催化环酮与芳香醛的反应,以中等的产率、较高的dr值与ee值得到Aldol反应产物,实现了MacMillan催化剂在水相中对Aldol反应的催化。

A chiral MacMillan catalyst was synthesized and used with acid in the direct Aldol reactions in water as organocatalyst. Using the catalyst the aldol product was obtained in much higher dr values, ee values and yield in comparison to that was observed using other ganocatalysts.