弹性蛋白与慢性阻塞性肺疾病

Elastin and chronic obstructive pulmonary disease

弹性蛋白是弹性纤维最主要和最具特征性的蛋白，主要分布在富有弹性的组织。弹性蛋白是影响肺发育和肺功能的一个重要因素，近年来弹性蛋白及其降解产物弹性蛋白多肽片段在慢性阻塞性肺疾病（chronic obstructive pulmonary disease,COPD）发病机制中的作用日益受到人们的关注。本文介绍了弹性蛋白与肺发育的关系，并进一步阐述了其在COPD发病中的作用。

Elastin, as the most important and specific protein of elastin fiber, mainly distributes in those elastic tissues. Elastin protein is one of the key factors that plays an important role in normal lung development and functions. In recent years,more and more attraction has been paid for the effects of elastin and elastin fragments on the pathogenesis of chronic obstructive pulmonary disease （COPD）. This review introduces the relationship between elastin and lung development, also the effect of elastin in COPD is well explained.