内皮素1在急性呼吸窘迫综合征炎症反应中的作用

Role of endothelin-I in inflammation of acute respiratory distress syndrome

目前认为，炎症反应是急性呼吸窘迫综合征 （acute respiratory distress syndrome, ARDS）发病的重要机制。许多研究证明，内皮素1在ARDS炎症反应中发挥促炎作用。本综述通过回顾内皮素系统的研究进展，阐述内皮素1的炎症作用在ARDS的病理生理学机制、通透性肺水肿及肺动脉高压形成中的作用，及内皮素受体拮抗剂的应用现状。

Inflammatory reaction may play an important role in the pathogenesy of acute respiratory distress syndrome（ARDS）. As a number of studies have proven, the inflammatory effect of endothelin-1 （ET- 1） has been implicated in the pathophysiology of ARDS. This review will focus on the biology of ET-1 and its role as a inflammatory mediator in the pathogenesy of ARDS, the formation of pulmonary edema and pulmonary hypertension. And the recent application of endothelin receptor antagonists will be discussed.