原发性胆汁性肝硬化免疫学及病理特征分析

Laboratory findings and pathological characterization of primary biliary cirrhosis

目的探讨原发性胆汁性肝硬化（PBC）患者的临床及肝组织病理学特征。方法分析37例原发性胆汁性肝硬化患者的一般资料、免疫学标志及肝组织病理学特点。结果免疫功能检查AMA-M2阳性率为56．75％，GP210阳性率占13．51％，抗肝／肾微粒体抗体（LKM1）占8．10％，AMA—M2、GP210均阳性为16．21％，ANA阳性率为5．4％。肝脏病理改变以小胆管改变最明显，周围有炎性细胞浸润，汇管区细胞浸润现象明显，各期改变可相互混杂。结论PBC患者多见于中年女性，血清AMA—M2抗体检测可作为临床诊断PBC的重要血清免疫学指标。肝组织病理检查对PBC诊断及病程分期有重要意义。

Objective To study laboratory findings and pathological features of primary biliary cirrhosis （PBC） in order to facilitate cognition of the disease. Methods General status,laboratory findings and pathological features of 37 patients with PBC were reviewed. Results Positive rate of GP210 is 13.51% ,positive rate of LKM1 is 8. 10% ,positive rate of AMA-M2 and GP210 is 16. 21% ,positive rate of ANA is 5.4%. The main histopathologieal changes focus on small bile duct, inflammatory cell infiltrating around them, infiltration of cell in header, different stages might be merged. Conclusion It is mostly found in middle-aged women. AMA-M2 antibody detection is an important and seneetive sereimmunologieal marker for the diagnosis of PBC. Liver biopsy is useful to confirm the diagnosis and differentiate histopathological stages.