四类肝衰竭的临床特点及转归分析

Clinical characteristics and prognosis of four types of liver failure

目的研究各类肝衰竭的临床特点及转归。方法回顾性调查急性肝衰竭(ALF)25例、亚急性肝衰竭(SALF)34例、慢加急性肝衰竭(ACLF)121例、慢性肝衰竭(CLF)206例患者的实验室检查结果、常见并发症和预后。结果四类肝衰竭在临床生化指标(包括白蛋白、转氨酶、胆碱酯酶和胆红素)、并发症和预后方面均有差异,预后的优良顺序为CLF>ACLF>SALF>ALF。结论四类肝衰竭的临床特点及其预后均有差异。肝衰竭指南符合国情,有较强的科学性及临床应用价值。

Objective To study the clinical characteristics and prognosis of patients with liver failure. Methods A retrospective study was made to analyze biochemical indicators, complications and prognosis in 25 cases of acute liver failure （ALF）, 34 cases of subacute liver failure （SALF）, 121 cases of acute-on-chronic liver failure （ACLF） and 206 eases of chronic liver failure （CLF）. Results There were significant differences in biochemical indicators, such as albumin（ALB）, alanine aminotransferase （ALT）, cholinesterase （CHE） and bilirobin, complications and prognosis in four types of liver failure. In the four groups, CLF group had the best prognosis, then ACLF group, SALF group, and ALF group. Conclusion There are differences in clinical characteristics and prognosis in four types of liver failure, so the guideline for liver failure is scientific and valuable clinically for Chinese.