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抗中性粒细胞胞浆抗体、抗核抗体联合检测 被引量:1

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摘要 目的探讨抗中性粒细胞胞浆抗体(ANCA)与抗核抗体联合检测的临床意义。方法应用间接免疫荧光法(IIF)检测疑似自身免疫性疾病患者血清中的ANCA和抗核抗体(ANA),并用ELISA法进行抗丝氨酸蛋白酶3(PR3)和抗髓过氧化物酶(MPO)的定量检测。结果(1)在ANA阳性组和ANA阴性组中均检出ANCA,但ANA阳性组的阳性率(15.64%)高于ANA阴性组(3.25%)(P<0.01)。(2)ANCA阳性组以抗MPO和抗PR3升高为主,与ANCA阴性组比较有统计学差异(P<0.01)。结论同时进行ANCA、ANA检测,有助于提高自身免疫性疾病的诊断。
出处 《江苏医药》 CAS CSCD 北大核心 2008年第10期1054-1055,共2页 Jiangsu Medical Journal
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