蓇密牌钙片对大鼠骨密度的影响研究

Research on the effects of Gumipai calcium tablet on rat's bone mineral density

目的研究蓇密牌钙片对大鼠骨密度的影响。方法选用雌性Wistar大鼠50只,随机分成5组;每周量身长;给予该产品4周后,进行3天代谢实验;实验结束时,进行股骨骨密度测定和骨钙含量的测定。结果低、中剂量实验组的身长和身长净增加值显著高于低钙对照组(P<0.05或P<0.01)。各剂量实验组大鼠股骨中心矿物质含量和骨密度显著大于低钙对照组(P<0.01或P<0.05),高剂量实验组大鼠的股骨中心矿物质含量和骨密度显著高于碳酸钙对照组(P<0.05)。高剂量实验组大鼠的股骨远心端骨矿物质含量和骨密度显著大于低钙对照组(P<0.01)。中、高剂量实验组大鼠的股骨钙含量及总钙量显著大于低钙对照组(P<0.01)。中、高剂量组、碳酸钙对照组大鼠钙的表观吸收率显著低于低钙对照组(P<0.01)。中、高剂量实验组和碳酸钙对照组大鼠钙的存留率显著低于低钙对照组(P<0.01)。结论认为蓇密牌钙片有增加大鼠骨密度的作用。

Objective To study the effects of Gumipai calcium tablet on bone mineral density. Methods 50 female rats were randomly divided into five groups ： After 4 weeks of treatment the rats, whose height was measured each week, were tested on the metabolic aspect there days;At the end of experiment, bone density and the calcium content of the bone were measured. Results The rats height scale and net scale of the low and middle dose of Gumipai calcium tablet were significantly high compared with the low calcium group（ P 〈 0.05 or P 〈 0.01 ）. The content of the mineral of the bone and the bone density of each experiment rats group, was significantly high compared with the low calcium group. Compared with the low calcium group, calcium apparent absorption of the middle and high dose of Gumipai calcium tablet group, was significantly decreased （P 〈 0.01 ）. Compared with the low calcium group, calcium retention ratio of the middle and high dose of Gumipai calcium tablet group, was significantly increased（ P 〈0. 01 ）. Conclusion Gumipai calcium tablet was effective in increasing rats BMD.