补肾壮骨颗粒剂对老年男性骨转换指标的影响

The effect of herb of invigorating the kidney,the spleen and promoting blood flow on old men's bone transition index

目的观察补肾健脾活血中药对老年男性骨密度(BMD)、骨特异性碱性磷酸酶(BAP)、抗酒石酸酸性磷酸酶5b(TRAP5b)、氨基端和中段骨钙素(BGP)的影响。方法采用自身前后对照的方法,临床选取符合骨量减少及骨质疏松患者的老年男性病例35例,平均年龄(75.56±5.8)岁,给予口服补肾壮骨颗粒剂,钙尔奇D片和法能胶丸做为基础用药。分别测定服药前及服药半年后患者BMD、BAP、TRAP5b、BGP 4项骨转换指标,并将服药前后测定值做比较。结果服药半年后患者的BMD及BAP较服药前升高明显(P<0.05),有统计学意义;TRAP5b较服药前降低(P<0.05),有统计学意义;而BGP服药前后改善不明显,(P>0.05),无统计学意义。结论补肾健脾活血中药与钙剂、维生素D联合应用,能抑制骨吸收,降低血清TRAP5b;促进骨形成,提高血清BAP及BGP含量,减缓骨量丢失,提高骨密度,有效防治老年男性骨质疏松症。

Objective Observing influence of herbs of invigorating the kidney, the spleen and promoting blood flow on bone density（BMD）, bone specificity alkaline phosphatase（BAP）, tartrate-resistant acid phosphatase 5b （TRAPSb） and osteocalcin（BGP） of old men. Methods Select 35 patients according to the diagnostic criteria of osteopenia and osteoporosis, with the mean age （75.56 _＋ 5.8 years）;determine BMD,BAP,TRAPSb,BGP before and after taking these herbs and calcium, Alfacalcidol for half a year, and compare the determining these results. Results After taking these medicine for half a year, BMD and BAP advanced（ P 〈 0.05） ,TRAP5b degraded （ P 〈 0.05 ）, while BGP didn＇t improve obviously （ P 〉 0.05 ）. Conclusion Using herbs of invigorating the kidney, the spleen and promoting blood flow with calcium, Alfacalcidol can inhibit bone resorption, depress serum TRAP5b; promote bone formation, elevate serum content of BAP and BGP, slow loss of bone mass, raise bone density, prevention and cure osteoporusis of old men.