脑膜癌病4例临床分析

Clinical analysis of leptomeningeal carcinomatosis in 4 cases

目的探讨脑膜癌病的临床、MRI和脑脊液细胞学特点。方法对4例脑膜癌病患者的临床表现、MRI、脑脊液细胞学改变等进行分析。结果头痛等颅高压表现出现于所有患者;MRI见到脑室扩大和不同程度脑膜强化;脑脊液检查发现细胞数高、蛋白增高,糖和氯化物降低,脑脊液细胞学检查发现癌细胞。结论脑膜癌病容易误诊为感染性脑膜炎,脑脊液细胞学检查对本病具有诊断意义。

Objective To analyze the characteristics of leptomeningeal carcinomatosis. Methods We summarized the clinical presentation, magnetic resonance imaging （MRI） findings and eerebrospinal fluid （CSF） cytological findings in 4 cases of leptomeningeal carcinomatosis. Results All the patients presented with signs of elevated intracranial pressure such as headache. Enlarged cerebral ventricles and dural enhancement were found by MRI, with also the presence of malignant cells in cytological slides. Conclusion CSF cytological examination is important for diagnosis of leptomeningeal carcinomatosis.