脑死亡供肝与无心跳供肝对肝移植患者近期预后的影响

Comparison of the short-term outcomes of liver transplant recipients receiving liver grafts from brain-death and non-heart-beating donors

目的比较脑死亡供体与无心跳供体来源供肝对肝移植患者术后短期预后的影响,初步探讨脑死亡供体来源供肝应用于临床的安全性。方法2006年1月至2007年12月中山大学附属一院器官移植科共实施成人首次全肝移植130例,其中9例接受脑死亡供体供肝(脑死亡供体组),121例接受无心跳供体供肝(无心跳供体组),回顾性分析了以上130例患者的术中、术后情况,比较两组患者术中出血量、手术时间、无肝期时间、术后SICU治疗时间、各种并发症的发生率及术后近期生存情况(围手术期、术后6月及术后12月生存率)的差异。结果两组间手术时间、无肝期时间和术中出血量无明显差异,术后1月、6月、12月生存率无明显差异(P>0.05),术后各种并发症的发生率无明显差异。结论脑死亡供体来源的供肝与无心跳供体来源的供肝相比,移植肝及受者术后早期预后无明显差异。

Objective To compare the short-term outcomes of liver transplantation recipients receiving liver grafts from brain-death and non-heart-beating donors and evaluate the safety of liver grafts from brain-death donors. Methods A total of 130 patients receiving liver transplantation between January, 2006 and December, 2007 were retrospectively analyzed, including 9 patients receiving liver graft from brain-death donors and 121 with grafts from non-heart-beating donors. The operative time, anhepatic time, bleeding volume, postoperative complications and short-term survival were compared between the two groups. Results The operative time, anhepatic time, bleeding volume, postoperative complications and short-term survival showed no significant differences between the two groups. Conclusions The short-term outcome of recipients receiving liver grafts from brain-death donors is similar to that of recipients receiving grafts from non-heart-beating donors, indicating the safety of clinical use of the liver grafts from brain-death donors.