复方樟柳碱联合尼莫地平治疗视网膜中央动脉阻塞疗效观察

Combined therapy of compound anidodine and nimodipine for central retinal artery occlusion

目的探讨应用复方樟柳碱和尼莫地平等综合治疗视网膜中央动脉阻塞的疗效。方法随机将31例(31只眼)视网膜中央动脉阻塞患者分为治疗组18例(18只眼)和对照组13例(13只眼)。对照组采用硝酸甘油、654-2、醋氮酰胺、复方丹参和水蛭地龙治疗,同时输氧等常规治疗;治疗组除应用同对照组相同的药物外,另予复方樟柳碱作患侧颞浅动脉旁皮下注射,全身应用尼莫地平治疗。以视力、视野、眼底改变为疗效判断指标。结果对照组有效率为53.85%,观察组有效率为88.89%。其差异具有显著性意义(P<0.05)。结论应用复方樟柳碱和尼莫地平等综合治疗视网膜动脉阻塞能够取得较好的疗效。

Objective To investigate the effect of combined therapy of compound anidodine injection and Nimodipine injection on treatment of cental retinal artery occlusion（CRAO）. Methods The 31 patients（31 eyes） were assigned into 2 groups randomly：IS patients（ 18eyes ） in treatment group and 13 patients（ 13eyes） in control group. Glycerol trinitrate,654-2,Acetazolamide,compound salvia miltiorrhiza , leech and oxygen therapy were used for the control group, While compound anidodine injection was injected subcutaneously around superficial temporal artery and Nimodipine injection was injected by the vein for the treatment group, including the same treatment as the control group. Visual acuity, visual field and fundus condition were examined to evaluate the effects of the therapy. Results The difference of effective rate between the treatment group （88.89%） and the control group （53.85% ） was significant （ P 〈0.05）. Conclusion The combined therapy of compound anidodine injection and Nimodipine injection can improve the curative effect of CRAO.