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异位ACTH综合征的糖皮质激素抵抗机制研究进展

Progress in the mechanisms of glucocorticoid resistance in ectopic ACTH syndrome
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摘要 异位ACTH综合征患者一个典型的特征就是其高ACTH水平不受内源或外源性糖皮质激素的抑制，即仔在着糖皮质激素抵抗，但其抵抗机制目前所知甚少，明确其机制将有助于对该疾病的诊断和治疗。本文综述了糖皮质激素受体前、受体和受体后抵抗的发生机制。 High level of ectopic serum ACTH can not be suppressed by endogenous or exogenous glucocorticoid, this is the cardinal characteristic of ectopic ACTH syndrome （ EAS）, that is to say there exists glucocorticoid resistance in EAS. However, the mechanism of glucocorticoid resistance remains unclear. Identifying the mechanism can help us to diagnose and treat the disease. This review focuses on the mechanism of glucocorticoid resistance from several aspects, including the pre-glucocorticoid receptor （GR）, GR and post-GR.
作者 李娜 李小英
机构地区 上海交通大学医学院附属瑞金医院内分泌代谢科
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2008年第6期686-688,共3页 Chinese Journal of Endocrinology and Metabolism
基金 基金项目：上海市浦江计划（05PJ14060）
关键词 ACTH综合征 异位 糖皮质激素抵抗 转录调控 ACTH syndrome, ectopic Glucocorticoid resistance Transcription regulation
分类号 R586 [医药卫生—内分泌]
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中华内分泌代谢杂志
2008年 第6期

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