摘要
对不同免疫状态小鼠造成孢子丝菌实验性感染，观察碘化钾的治疗作用和病损发展过程中病原体与炎症浸润细胞的变化及两者间的关系。结果进一步证实碘化钾对孢子丝菌病的治疗作用与宿主的免疫力有关，并发现碘化钾具有促进巨噬细胞在感染部位的浸润和增强小鼠对孢子丝菌的抵抗力，还表明碘化钾对小鼠内脏感染无效，而对血源播散型皮肤感染的作用因小鼠的免疫状态而异。
In this study,experimental infection of Sporotrichum schenckii was produced in normal and immunosuppressed mice.The effects of potassium iodide treatment were observed in reation to the changes of the micro-organisms and the inflammatory cells of the hosts during the development of experimental lessions.The results confirmed that the therapeutic effect of potassium iodide on sporotrichosis was related to the host immuno-mechanism.Evidence indicated that the potassium iodide might promote macrophayes infiltration in the sites of infection and promote the host resistant agaist sporotrichosis.The results showed that potassium iodide was not effective in treating systemic sporotrichosis of mice.Its effect on the disseminated cutaneous form of sporotrichosis was varied according to the mouse immunologic status.
出处
《中国皮肤性病学杂志》
CAS
北大核心
1998年第1期17-18,共2页
The Chinese Journal of Dermatovenereology
