23例t(8;21)急性粒细胞白血病

23 Cases of Acute Myelocytic Leukemia with t(8;21)

通过观察23例伴t（8；21）的急性粒细胞白血病临床表现、血液学异常、AML1－ETO融合基因及治疗效果，结果显示：AML1－ETO融合基因可作为急性粒细胞白血病M3b的分子标志物；本组病例完全缓解率61％，疗效与其他类型急性白血病相似；肝脾肿大是预后不良因素之一。

We observed the clinical manifestation, hematologic abnormalites,AML1-ETO chemeric gene and therapeutic response in twenty-three acute myelo cytic leukemla patients with t(8; 21) chromosomal abnormality, the results showed that AML1-ETO gene can be regarded as a molecular marker of acute myelocytic leukemia subtype M2b The complete rerilission of these cases is 61% and has a same response to treatment with other acute leukemia subtype. The hepatosplenomegaly is one of bad prognostic factors.