Graves病1:2配比病例对照研究

Matched CaseControl Study of Graves'Disease

在门诊同位素科进行Ｇｒａｖｅｓ病１：２配比的病例对照研究，旨在检验吸烟、生活事件、遗传、感染与Ｇｒａｖｅｓ病的关系。单因素分析结果表明：吸烟、感染、工作事件、家庭事件是Ｇｒａｖｅｓ病的危险因素。多因素分析结果表明：吸烟、家庭事件、感染是Ｇｒａｖｅｓ病的危险因素，但以家庭事件与Ｇｒａｖｅｓ病关联强度最大（ＯＲ＝７．０７），提示减少家庭生活事件可能减少Ｇｒａｖｅｓ病的发生。遗传因素分析结果：病例组一级亲属患病比例为６／７１，对照组比例为１／１４２。

We have analyzed the risk factors of Graves'disease by 1:2 matched casecontrol study in the outpatient in order to examine relationship between smoking,life events,hereditary,infection and Graves'disease.The result of univariate analysis showed that smoking,infection,working events,family events are the risk factors of Graves′ disease.Family events and infection,smoking, are the risk factors of Graves'disease.The result of multivcariate analysis showed that the association of family events and Graves'disease is very large(OR=7 07),controling family events may reduce incidence rate of Graves disease.In addition,the result of heriditary analysis is that proverlance perportion of first relatives in cases is 6/71,then in controls is 1/142.