摘要
对９８名６５～７５岁的健康退休工人分别用放射免疫分析和免疫放射法测定血浆２５（ＯＨ）Ｄ和ＰＴＨ的含量，应用ＤＰＸ－Ｌ双能骨矿测定仪测定腰椎及髋部ＢＭＣ。结果表明：（１）该人群春季血浆２５（ＯＨ）Ｄ水平较低，男性为１１．４±５．０ｎｇ／ｍｌ，女性为１５．５±５．３ｎｇ／ｍｌ，其水平与腰椎及髋部ＢＭＣ没有关系。（２）老年女性血浆２５（ＯＨ）Ｄ浓度与血浆ＰＴＨ浓度呈负相关，而这种关系在老年男性不存在。（３）老年女性骨面积和体重身高校正后的股骨颈ＢＭＣ与血浆ＰＴＨ浓度呈反向关系，但其它部位ＢＭＣ以及老年男性所有部位ＢＭＣ均与血浆ＰＴＨ浓度无关。
To examine the relation between vitamin D,parathyroid hormone (PTH) and bone mineral content (BMC) in male and female elderly,we studied 98 healthy retired workers aged 65～75 years.Plasma 25(OH)D and PTH were determined by RIA and IRMA respectively.BMC of spine and hip waw measured using DPXL Densitometer.Results showed that(1) Plasma 25(OH)D levels were low in these subjects with mean values of 115±50ng/ml in males and 155±53ng/ml in females BMC.(2)There was a negetive relationship between 25(OH)D and PTH in females (r=-041 P<0005) but not in males.(3) BMC of femur neck was negetively related with PTH level in females after adjusting by bone area and body weight.However,the relationship was not found at other sites of bone measuriement of females and also not found at any sites of bone measurement of males.We conclude that the influence of these two hormones on bone netabolism may different in female and male elderly but more studies are needed to justify the consideration.
基金
国际Sandoz老年基金
