内皮素和一氧化氮对烧伤早期大鼠心肌血供的影响

Effect of the endothelin and nitric oxide on myocardial blood flow in rats after severe burn injury

目的：观察烧伤早期心肌血液灌注的变化，探讨内皮素和一氧化氮（ＥＴｓ和ＮＯ）对心肌血供的影响。方法：以３０％ＴＢＳＡⅢ度烧伤大鼠模型，测定烧伤前及烧伤后１、３、６、１２和２４小时心肌营养性血流（ＮＢＦ）、ＥＴｓ、ＮＯ含量及ＥＴｓ／ＮＯ比值变化。结果：烧伤后心肌ＮＢＦ迅速大幅度下降，心肌组织ＥＴｓ及ＮＯ含量明显增加，ＥＴｓ／ＮＯ比值升高；心肌ＮＢＦ变化与ＥＴｓ／ＮＯ比值密切相关。结论：烧伤早期心肌ＥＴｓ及ＮＯ产生增多，调控紊乱，ＥＴｓ／ＮＯ比值增加可能是影响心肌血供的重要因素之一。

Objective:To observe changes in myocardial blood flow and effect of endothelin and nitric oxide (ETs and NO) on myocardial blood flow after severe burn injury.Methods:Myocardial nutritio blood flow (NBF),ETs and NO levels as well as the ration of ETs/NO were measured prior to burn injury and 1,3,6,12,24 hours postburn in rats subjected to full thickness burn of 30% TBSA.Results:After severe burn injury NBF decreased markedly,and ETs and NO contents and ETs/NO ratio in myocardium increased significantly.Concomitantly,there was positive relationship between NBF and ETs/NO.Conclusions:The elevation of ETs and NO contents and ETs/NO ratio may play an important role in reducing myocardial blood flow after severe burn injury.