基于标准结构熵的PPI网络可靠性研究

Research on robustness of PPI networks based on normalized entropy

由蛋白质相互作用构成的PPI网络的拓扑特性分析是后基因组时代最重要的研究课题之一。应用标准网络结构熵对DIP数据库中七个物种的八个PPI网络的异质性和可靠性进行分析与研究。分析结果表明,这些PPI网络具有典型的无尺度特性,对随机移除不超过10%的顶点都具有很好的鲁棒性,但对有选择地移除2%的高度顶点就开始表现出极弱的抗攻击性。

Analysis of the topology characters of PPI network composed of protein-protein interactions is one of the most important issues in the post-genomic era. This paper analyzed the heterogeneity and robustness of 8 PPI networks of 7 species in DIP database by using ormalized entropy. Analysis shows that these PPI networks are all scale-free, which are robust against the random removal of not more than 10% nodes, but are vulnerable to the removal of 2% nodes of high degree.