晚期妊娠引产产妇血浆及脐血中的米非司酮浓度测定

HPLC assay for mifepristone level in plasma and umbilical cord blood of parturient

采用高效液相色谱法（ＨＰＬＣ）测定产妇血浆及脐血中米非司酮血药浓度。结果显示：对照组（正常产妇）妊娠晚期体内含有内源性米非司酮类似物，产程进入活跃期后无明显变化；服药组（口服米非司酮１５０ｍｇ）产程活跃期静脉血中米非司酮浓度１．１μｇ·ｍｌ－１，此结果与宫颈成熟度、产程长短等临床指征的变化相对应，说明米非司酮的抗孕酮作用与其浓度相关，并存在明显的个体差异。服药组产妇脐血米非司酮浓度明显高于对照组，表明米非司酮可以透过胎盘屏障，进入脐血，透过量与母体产程活跃期时的血中药物浓度成正比。

Mifepristone compatible with misoprostol was used for inducing labor in late pregnancy.The mifepristone concentration in plasma and umbilical cord blood was measured by HPLC.The conclusion indicated:there was endogenous mifepristone in the control group (normal parturient),and no change in activation period.In venous blood of the experimental group (who took mifepristone 150 miligram),the mifepristone concentration was 1.1μg·ml-1.This result corresponds to clinical signs such as Bishop score increasings,uterine neck softings,labor shortings and so on.This means antiprogestin effect of mifepristone is related to its concentration,and there exists individual differences.The mifepristone concentration in umbilical cord blood in the experimental group is obviously higher than in the control group.This includes mifepristone which can transport through the placental barrier,and the mass of transportation has a direct ratio with the drug concentration in the activation period.