脑灵片与广防己共煎后马兜铃酸A含量的变化

Study on the effect of single decoction and decocted with Naoling tablet on content of Aristolochic acid A from Aristolochiae fangchi

目的:通过研究脑灵片对广防己中马兜铃酸A含量的影响,以初步探讨对广防己的解毒问题。方法:广防己与脑灵片共煎后用RP-HPLC法测定马兜铃酸A的吸收值,观测其含量的变化情况。结果:加入脑灵片后,广防己中马兜铃酸A的含量明显降低。结论:脑灵片可显著降低广防己中马兜铃酸A的含量。

Objective ： To study the effects of Naoling tablet on Aristolochia acid A from Aristolochia fangchi ,preliminary explore the deintoxication of Aristolochia fangchi. Methods ： Absorption value of Aristolochhia aicd A was determined by HPLC after Aristolochi fangchi decocted with Naoling tablet, the change of content of Aristolochia acid A was observed. Results： the content of Aristolochia acid A from Aristolochia fangchi was markedly decreased after Naoling tablet was added.Conclusion ： Naoling tablet can markedly decreased the content of Aristolochhia aicd A from Aristolochia fangchi.