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微管相关蛋白_(30)和ubiquitin在老年性痴呆病神经元纤维缠结中的表达 被引量:3

Microtubuleassociated protein_(30) (MAP_(30)) and ubiquitin detectedin neurofibrillary tangles of Alzheimer's disease brains
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摘要 采用尸检脑组织标本,经免疫组织化学染色观察微管相关蛋白30(MAP30)和ubiquitin免疫反应产物在老年性痴呆病(AD)患者海马内神经元的分布及变化,探讨微管相关蛋白与AD发病机制之间的关系。MAP30和ubiquitin免疫染色显示海马内神经元的神经纤维缠结(NFT)。MAP30与ubiquitin免疫反应阳性神经元密度差异无显著性;二者在CA1和CA2区阳性神经元数密度明显高于CA3及CA4区。结果表明MAP30和ubiquitin参与NFT的形成。 Using immunohistochemical technique, the distribution of immunoreactive products of antiubiquitin and MAP_(30) in the neurons of hippocampus of Alzheimer's disease (AD) brain were studied. Nurofibrillary tangles (NFT), dystrophic neurites in plaques and neuropil threads were labeled by the antibody of ubiquitin. NFT and pretangle neurons (PTN) were stained by the antibody of MAP_(30), but not detectable signal in axons or distal dendrites. The neurons immunostained with antibodies to ubiquitin and MAP_(30) were found in all the areas of CA1,CA2,CA3 and CA4 of hippocampus of AD. These neurons labeled by 2 antibodies used in this study were distributed more in the CA1 and CA2 than those in CA3 and CA4. The results indicat that ubiquitin is seen associated when NFT is already formed, and MAP_(30) may be a novel antigenic component of NFT in Alzheimer's disease.
作者 刘正清
出处 《湖南医科大学学报》 CSCD 1998年第1期11-13,共3页 Bulletin of Hunan Medical University
基金 湖南省卫生厅中医药科研基金
关键词 痴呆 神经元 NFT 老年性痴呆 UBIQUITIN MAP30 Alzheimer disease microtubuleassociated protein neurofibrillary tangle ubiquitin paired helical filament*
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  • 1刘正清,Fourth joint meeting Robinson College,1995年,35页
  • 2郑富盛,细胞形态立体计量学,1990年,8页

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