男性冠心病患者血浆睾酮的变化

Changes of plasma testosterone level in male patientswith coronary heart disease

测定１１８名男性冠心病患者和５３名性别、年龄匹配的健康对照者的血浆睾酮（Ｔ）、雌二醇和血脂水平。结果显示：冠心病患者的血浆Ｔ水平明显低于对照组（Ｐ＜０．０１）；Ｔ水平与高密度脂蛋白胆固醇（ＨＤＬ－Ｃ），ＨＤＬ３－Ｃ水平及ＨＤＬ－Ｃ／ＴＣ呈正相关，与收缩压、载脂蛋白Ｂ１００和脂蛋白ａ呈负相关。Ｌｏｇｉｓｔｉｃ回归分析表明。

The plasma testosterone (T), estrodiol (E), total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesteral (HDL-C), HDL2C, HDL3C, apolipoprotein (apo) A1 and B100, and lipoproein (a) were measured in 118 male patients with coronary heart disease (CHD) and 53 sex and agematched healthy controls. The results showed that plasma T, HDLC, HDL3C levels and HDLC/TC ratio were significantly lower and Lp(a) level was significantly higher in patients than in the controls. After adjusting body mass index, blood pressure and fasting blood glucose, the difference of plasma level between patients and controls persisted. Plasma T level correlated positively with the HDL-C, HDL3C level and HDL-C/TC ratio and negatively with systolic blood pressure, apoB100 and Lp(a) level. Logistic regression was used to analyze the data, and this indicated that decreased T and HDL3C levels, and increased Lp(a) level were the independent risk factors of CHD.