肾性高血压动物红细胞变形性及内皮素的研究

Erythrocyte deformability and endothlin study of renal hypertensive animals

目的研究高血压对脑动脉的病理影响及实验性高血压时红细胞变形性的改变。方法肾性高血压兔及正常对照兔各１０只，进行脑病理观察，测定红细胞变形指数，测定血浆及脑组织内皮素（ＥＴ）含量。结果发现肾性高血压兔脑动脉普遍性管壁增厚，管腔缩小，脑组织有缺血和出血性病变，红细胞变形能力下降，血浆及下丘脑和颞叶皮层脑组织ＥＴ含量增高，且正常兔和高血压兔下丘脑ＥＴ浓度均高于相应的颞叶皮层。结论高血压小动脉病变是脑血管病的病理基础，ＥＴ可能是一种神经递质类物质，参与调节高血压。

Objective To research the pathological changes of cerebral arteries and RBC deformability in experimental hypertensive animal model.Methods We made the hypertensive animal models by constricting the renal arteries in rabbits(2k 2c method).We set two groups of rabbits for studying the RBC deformability and the contents in plasma and certain area of cerebral tissue.One group was the expermental group including 10 rabbits of hypertension.The other,the control group included 10 normal rabbits.Results In renal hypertensive rabbits,pathological finding of brain revealed that general thickened wall was present in cerebral arteries,especially small arteries,there were hemorrhagic and ischemic lesions in cerebral tissues.RBC deformability of renal hypertensive rabbits decreased significantly.Endothelin is a potent vasoconstrictive peptide.Increased levels of ET had been found in plasma,hypothalamus and right temporal cortex of hypertensive rabbits.Both renal hypertensive models and control animals,ET concentrations in hypothalamus were higher than in temporal cortex.Couclusion These results indicated that ET in central nervous system might be a sort of neurotransmitters which played important role not only in hypertensive vascular diseases but also in many other aspects.