82株淋病奈瑟菌的耐药性分析

Analysis on antibiotic resistance of 82 strains of neisseria gonorrhoeae

目的了解本地区淋病奈瑟菌的耐药性,为临床治疗提供实验依据。方法细菌鉴定采用API鉴定条,药敏试验采用K-B法,并进行统计分析。结果82例淋病奈瑟菌中,产β-内酰胺酶菌株25株,阳性率为30.5%;淋病奈瑟菌对大观霉素、头孢曲松较敏感,对青霉素、环丙沙星有较高的耐药性。结论青霉素、四环素以及氟喹诺酮类药物已不宜作为本地区治疗淋病的常规药物;大观霉素、头孢曲松可作为治疗淋病的首选药物,同时应加强淋病奈瑟菌的耐药性监测。

Objective To investigate antibiotic resistance of neisseria gonorrboeae and to provide a guidance to clinical rational use of antibiotics. Methods Identification of bacteria was performed with API and disc diffusion test（ K-B method）was used to study the drug resistance of isolated from clinical source. The date analysis were made with whonet 5.4 software. Results 25 strains were considered producing β-lactamase in 82 strains of Neisseria gonorrhoea,the positive rate was 30. 5%. Neisseria gonorrhoea was more sensitive to spectinomycin and ceftriaxone,but it was resistive to penicillin and eiprolloxacin seriously. Conclusion Penicillin, tetracycline and fluoroquinolone drugs have been inappropriate treatment of gonorrhea in the region as the conventional drugs, but spectinomycin and ceftriaxone can be used as the first choice of drug. We should strengthen the monitoring of drug resistance in Neisseria gonorrhoeae.