NJ967抗炎作用的研究

Antiinflammatory action of NJ967

目的研究非甾体类抗炎新药—ＮＪ９６７的抗炎作用。方法采用角叉菜胶诱导的大鼠急性足爪肿胀模型和福氏完全佐剂诱导的大鼠佐剂性关节炎模型。结果ＮＪ９６７２５，５０，１００ｍｇ·ｋｇ－１灌胃给药可明显抑制大鼠急性足爪肿胀，其半数抑制量（ＩＤ５０）为７６ｍｇ·ｋｇ－１；该剂量的ＮＪ９６７预防与治疗给药，每天灌胃１次，连续７天亦可抑制大鼠佐剂性关节炎继发性足爪肿胀。结论ＮＪ９６７具有较强的抗炎作用。

Objective To investigate the antiinflammatory action of NJ967 in rats. Methods Acute or secondary hind paw edema of rats induced by carrageenin or complete Frends adjunct (CFA) was applied respectively. Results NJ967 at doses of 25, 50 and 100 mg·kg-1 (ig) suppressed significantly the acute hind paw edema of rats with inducement of carrageenin, and its ID50 was approximately 76 mg·kg-1; the secondary hind paw edema of rats with inducement of CFA was remarkedly inhibited by way of pretreatment or treatment with NJ967 at above doses in seven days succession, respectively. Conclusion NJ967 had a definite antiinflammatory effect on rats.