胃癌与血管活性肠肽关系初探

Relationship between vasoactive intestinal peptide and gastric cancer

目的了解胃癌血浆及组织中血管活性肠肽（ＶＩＰ）水平，探讨其对胃癌生长的影响。方法采用放射免疫分析法测定３８例胃癌组织、癌旁粘膜（１ｃｍ、５ｃｍ）及肿瘤区和外周血浆中ＶＩＰ含量，以１５例非癌症患者进行对照。结果胃癌患者外周血浆ＶＩＰ含量明显高于对照组（Ｐ＜０．０１）；癌组织及癌旁１ｃｍ粘膜ＶＩＰ含量均显著高于癌旁５ｃｍ粘膜含量；血浆ＶＩＰ水平与癌旁１ｃｍ粘膜、肿瘤区血浆及癌组织中ＶＩＰ含量间存在线性关系。结论胃癌组织及癌旁粘膜合成与分泌ＶＩＰ增加是血浆ＶＩＰ升高的主要原因，它对胃癌自身具有促生长调节作用。

Objective To explore the roles of vasoactive intestinal peptide (VIP) in the growth of gastric cancer and the content of VIP in serum, and tissue of patients with gastric cancer. Methods The content of VIP in serum, carcinomatous tissue and its surrounding mucosa (1 cm, 5 cm) were determined from 38 patients with gastric cancer by radioimmunoassay, and from 15 patients without cancer as controls. Results The content of VIP in serum of patients with gastric cancer was significantly higher than that in the controls(P<001). VIP levels of carcinomatous tissue and surrounding mucosa (1 cm) were higher than those in tumor surrounding mucosa (5 cm) (P<001). There was a linear relationship of VIP in serum to that in tumor surrounding mucosa (1 cm), blood of tumor area and carcinomatous tissue. Conclusions The synthesis and secretion of VIP in carcinomatous tissue and its surroungding mucosa is the major reason that the VIP level in serum increases. VIP may promote the growth of gasrtic cancer.