原发性青光眼外周血淋巴细胞CD_(44)和CD_(54)检出的临床意义

Clinical significance of peripheral blood lymphocyte CD_(44) and CD_(54) detecting with cytometry in primary glaucoma

目的研究原发性青光眼发生与发展过程中外用血淋巴细胞CD44及CD54表达量及其临床意义。方法28例原发性青光眼及28例健康人外周静脉血，经淋巴细胞分离、CD44-FITC及CD54-FITC免疫反应、流式细胞分析仪测定CD44及CD54表达量，并行统计学分析。结果原发性闭角型及开角型青光眼患者外周血淋巴细胞CD44及CD54表达量明显升高，与正常人比较，P＜0．01，差异有非常显著性意义。结论粘附分子CD44及CD54表达量升高与原发性青光眼发生与发展过程相关。CD44及CD54可能参与原发性青光眼发生与发展过程。

To study the content of CD44 and CD54 inperipheral blood lymphocyte (PBL) and its clinical significance in the pathogenesis and the development of primaryglaucoma.Methods 28 patients with primary glaucoma and 28normal persons were analysed by using flow cytometry(FCM)for PBL CD'' and CD.4.Results The content of PBL CD44 and CD.4 wassignificantly higher in primary glaucoma than that in normal persons (P＜0.01).Conclusions The higher Cuntent of PBL CD44 andCDs4 is associated with primary glaucoma. CD44 and CD.4maybe participat in the pathogenesis and the developmentof primary glaucoma.