柔红霉素预防后囊膜混浊的实验研究

Daunomycin preventing the posterior capsule opacification:the experimental study

目的通过动物在体实验探讨柔红霉素预防后囊膜混浊的作用及其临床可行性。方法采用0．5～10mg·L-1柔红霉素在兔眼晶体囊外摘除术中行囊袋内灌注10min（30例），以20mg·L-1柔红霉素作维持前房灌注（1例）。通过手术显微镜及扫描电镜观察术后眼组织反应。结果随访3mo发现，随用药浓度增加，后囊膜混浊发生率及严重程度下降，未发现角膜损伤及术后葡萄膜反应，较高浓度桑红霉素应用亦未造成明显的角膜内皮细胞改变。结论本研究表明应用桑红霉素1次性眼内灌注可减少后囊膜混浊发生率、且无邻近眼组织损伤。高效。安全、简便的用药特点提示柔红霉素在后覆膜混浊预防中具有临床应用价值及可行性。

To investigate the effect of daunomycin asa preventer of posterior capsule opacification (PCO), andthe applicability in clinical procession by animal experiments in vivo.Methods To infuse 0. 5～10mg·L-1 daunomycin into lens capsular bag for ten minutes during ECCE operationon rabbit eyes (30 cases) .and used 20mg·L-1 daunomycinfor continuous anterior chamber infusion (1 case ). ThePost-operative response of eye tissues was observed underoperation microscope and scanning electron microscope.Results With three months follow--up. it was foundthat the incidence and seriousness of PCO decreased whendrug concentration increased without any cornea damage orpostmoperative uveilis,and there also showed no significantchange of comeal ednothelial cells after using daunomycinof higher concentration.Conclusions The study Indicated that the incidence ofPCO could be reduced by single Intraocular infusion ofdaunomycin without toxicity to adjacent co[]lar tissues. Itshigh efficiency, safety alld simplicity suggest that daunomycln can be valuable and feasible for the prevention ofPesO during clinical application.