3种中药超微粉的药理作用观察

The Observation on Pharmacological Action of Three Chinese Herbal Ultra-fine Powder

为了研制和开发速效、高效的新型中兽药制剂,本试验分别观察了三七、元胡、大黄超微粉对小白鼠的凝血作用、镇痛作用和肠蠕动作用的影响。结果表明,三七超微粉和普通粉与对照组相比,三七超微粉具有显著的凝血作用(P<0.05),而三七普通粉凝血作用不显著(P>0.05);元胡超微粉和普通粉与对照组相比均具有显著的镇痛作用(P<0.05),但元胡超微粉比普通粉的镇痛作用显著(P<0.05);大黄超微粉和普通粉与对照组相比均具有极显著的促进肠蠕动作用(P<0.01),但是,在药物浓度相等时,大黄超微粉对肠蠕动的平均推进率比大黄普通粉促进肠蠕动的作用显著(P<0.05)。

The experiment was conducted to determine the effects of three Chinese herbal ultra fine powder on cruor effect, analgesic effect and enterokinesia in mice in order to study and develop a novel veterinary herbal medicine praeparatum with high efficiency and rapidly available. Compared with the control group, panax notoginseng ultra-fine powder has significant cruor effect（P〈0.05）. No obvious effects of panax notoginseng ordinary powder on the effect of cruor（P〉0.05）. Rhizoma corydalis ultra-fine powder has significant analgesic effect, when compared with control group and rhizoma corydalis ordinary powder group（P〈0.05）. Compared with control group, rhubarb ultra-fine and ordinary powder has significant promoting function on peristalsis of intestines（P〈0.01）. Moreover, there were significant differences in the average pushing rate of intestine enterokinesia between rhubarb ultra fine powder and ordinary powder group in the same drug concentration（P〈0.05）.