摘要
目的探讨不同类型糖尿病患者的血清干扰素γ诱导蛋白10(IP-10)水平及其意义。方法检测1型糖尿病(T1DM,n=78)、2型糖尿病(T2DM,n=49)和正常对照组(NC,n=33)的IP-10水平。T1DM组根据病情进展分为经典T1DM和成人隐匿性自身免疫糖尿病(LADA)组;又根据胰岛自身抗体IAA阳性与否分为自身免疫性T1DM和特发性T1DM组。T2DM组根据大动脉内中膜厚度IMT分为无动脉粥样硬化AS组和有AS组。Cl/SA检测各组IP-10水平。结果(1)IP-10水平在T1DM、T2DM与NC组之间无统计学差异。(2)胰岛自身抗体阳性的自身免疫性T1DM组IP-10水平高于NC组,差异有统计学意义,而T2DM与NC组无统计学差异;病程不同的T1DMIP-10水平无统计学差异。(3)伴或不伴动脉粥样硬化病变的T2DM亚组IP-10水平无统计学差异。结论自身免疫性1型糖尿病患者IP-10水平升高,可能与其介导Th1型细胞免疫反应有关。
Objective To investigate the significance of serum IP-10 levels in different types of diabetic patients. Methods Serum IP-10 level in 78 cases with type 1 diabetes, 49 cases with type 2 diabetes and 33 cases of healthy controls was measured with ELISA assays. Type 1 diabetic patients were divided into classic type 1 diabetes （n = 39） and latent autoimmune diabetes in adults （LADA, n = 39） according to their disease process, and they were also divided into autoimmune type 1 diabetes （n= 58） and idiopathic type 1 diabetes （n= 20）. Type 2 diabetic patients,according to carotid intima-media thickness （IMT）, were divided into patients with （n=24） or without atherosclerosis （n=25）. Results 1） Serum IP-10 levels were not statistically different among type 1 diabetes,type 2 diabetes and healthy controls. 2） Serum IP-10 concentrations in autoimmune type 1 diabetes with positive islet autoantibody were higher than those in healthy controls（184.96 4-104.48pg/ml vs 146.10 4- 74.61pg/ml, P = 0. 03）; while there were no difference in type 1 diabetes with variable disease durations. 3） No difference in IP-10 levels was found between type 2 patients with（173.54-69.6pg/ml） and without atherosclerosis （188.54-79.7 pg/ml）. Conclusions Serum IP-10 level is augmented in autoimmune type 1 diabetes
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2008年第12期728-731,共4页
Chinese Journal of Diabetes
基金
国家自然科学基金资助项目(30600298)
