PTEN和β-cat在尖锐湿疣、Bowen's病和皮肤鳞癌中的表达及意义

Expression of PTEN and β-cat in Condyloma Acuminatum,Bowns' and Cutaneous Squamous Cell carcinoma

目的:探讨PTEN和β-cat在尖锐湿疣、Bowen's病和皮肤鳞癌中的表达及意义。方法:采用免疫组化法检测蛋白PTEN和β-cat在正常皮肤、尖锐湿疣、Bowen's病、皮肤鳞状细胞癌(Scc)中的表达。结果:在正常皮肤、尖锐湿疣、Bowen's病、皮肤鳞状细胞癌(Scc)中PTEN蛋白的高表达率分别为100%,80.95%,46.67%,36.67%;β-cat蛋白的异常表达率分别为16.67%,30.16%,53.33%,70.00%,与正常皮肤组织相比,Bowen's病及Scc中PTEN蛋白的高表达率表达下降(P<0.05,P<0.01);β-cat蛋白的异常表达率明显升高(P<0.05,P<0.01)。在Scc中两者的表达呈负相关(r=-0.416,P<0.05)。结论:蛋白PTEN、β-cat在Scc的发生、发展中有重要的意义。

Objective：To investigate expression of PTEN andβ-cat in condyioma acuminatum,Bowns＇ and cutaneous squamous cell carcinoma.Methods：The expression of PTEN andβ-cat were detected by immuno-histochemical method in paraffin section of condyloma acuminatum,Bowns＇ and cutaneous squamous cell carcinoma.Results：In normal skin,condyloma acuminatum,Bowen＇s disease,Scc,the high lever expression of protein PTEN is 100%,80.95%,46.67%,36.67%;β-cat＇s abnormal expression rate is 16.67%, 30.16%,53.33%,70.00%,The high lever expression of protein PTEN in Bowen＇s disease,Scc reduced compared with the expression in control group （normal skin）（P〈0.05,P〈0.01）.Proteinβ-cat＇s abnormal expression rate of Bowen＇s,Scc had a elevation compared with the rate of the normal skin （P〈0.05,P〈0.01）.There＇s negative correlation between protein PTEN andβ-cat expression in Scc.（r=-0.416, P〈0.05）.Conclusion：The decreased expression of protein PTEN and the abnormal expression of proteinβ-cat were associated with the occurrence of Scc.