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肠促胰岛素在2型糖尿病中的作用和研究进展 被引量：4

Progressive in researches on effects of incretin in type 2 diabetes mellitus
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摘要 肠促胰岛素(Incretin)具有进食后刺激胰岛素分泌、促进胰岛素生物合成和抑制胰高血糖素分泌等多种生理功能,在维持血糖稳态上发挥了重要的作用。近年来,随着关于肠促胰岛素在2型糖尿病的发病机制和药物治疗方面的研究不断深入,为2型糖尿病的治疗提供了新的思路,开辟了新的途径。 Ineretin is released during nutrient absorption, and augments insulin secretion. Incretin can promote insulin biosynthesis and suppress glueagon secretion. Incretin plays an important role in the maintenance of glucose homeostasis. In recent years, with the development in studies on ineretin , we can understand of the pathogenesis of type 2 diabetes mellitus better and find a new way for the treatment.
作者 陈重 严励
机构地区 广东省人民医院内分泌科 中山大学附属第二医院内分泌科
出处 《国际内科学杂志》 CAS 2008年第12期696-698,718,共4页 International Journal of Internal Medicine
关键词 肠促胰岛素 葡萄糖依赖性促胰岛素分泌多肽 胰高血糖素样肽-1 糖尿病 2型 Incretin Glucose-dependent insulinotropic ploypeptide Glucagon like peptide-1 Diabetes mellitus, type 2
分类号 R587.1 [医药卫生—内分泌]
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参考文献19

  • 1De Leon DD, Crutchlow MF, Ham JY, et al. Role of glucagon-like Peptide-1 in the pathogenesis and treatment of diabetes mellitus, lnt J Biochem Cell Biol, 2006, 38 (5-6) : 845 -859.
  • 2Deaton CF. What do we know about the secretion and degradation of incretin hormones? . Regul Pept, 2005,128 (2) : 117-124.
  • 3Vilsbφll T, Krarup T, Sonne J, et al. Incretin secretion in relation to meal size and body weight in healthy subjects and people with type 1 and type 2 diabetes mellitus. J Clin Endocrinol Metab, 2003 , 88 (6) : 2706-2713.
  • 4Anini Y, Brubaker PL. Role of leptin in the regulation of glucagon-like peptide-1 secretion. Diabetes, 2003,52 (2) : 252-259.
  • 5Drucker DJ. The role of gut hormones in glucose homeostasis. J Clin Invest, 2007 ,117(1):24-32.
  • 6Freeman JS. The pathophysiologie role of ineretins. J Am Osteopath Assoe ,2007 , 107 (Suppl) : S6-S9 .
  • 7Vilsboll T, Agerso H, Krarup T, et al. Similar elimination rates of glucagons-like peptide-1 in obese type 2 diabetic patients and healthy subjects. J Clin Endocrinol Metab, 2003, 88( 1 ) :220-224.
  • 8Tokuyama Y, Matsui K, Egashira T, et al. Five missense mutations in glucagon-like peptide I receptor gene in Japanese population. Diabetes Res Clin Pract,2004,66 (1):63- 69.
  • 9Knop FK, Vilsbφll T, Hφjberg PV, et al. Reduced incretin effect in type 2 diabetes : cause or consequence of the diabetic state?. Diabetes, 2007 ,56(8) :1951-1959.
  • 10Nauck MA, El-Ouaghlidi A, Gabrys B, et al. Secretion of incretin hormones ( GIP and GLP-1 ) and incretin effect after oral glucose in first-degree relatives of patients with type 2 diabetes. Regul Pept, 2004,122 ( 3 ) : 209-217.

同被引文献20

  • 1Sinclair E M,Drucker D J.Proglucagon-derived Peptides:Mechanisms of Action and Therapeutic Potential[J].Physiology(Bethesda),2005,20:357-365.
  • 2Jones M C,Therapies for Diabetes:Pramlintide and Exenatide,2007,75(12):1833-1844.
  • 3Freeman JS.The pathophysiologic role of incretins.J Am Osteo-path Assoc 2007;107(Suppi):S6-S9.
  • 4Tokuyama Y,Matsui K,Egashira T,et al.Five missense mu-tations in glucagon-like pep tide 1 receptor gene in Japanese population.Djabetes Res Clin Pract 2004;66(1):63-69.
  • 5Drucker DJ.The biology of incretin hormones.Cell Metab2006;3:153-165.
  • 6Kolterman OG,Kim DD,Shen L,et al.Pharmacokinetics,pharmacodynamics,and safety of exenatide in patienta with type 2 dia-betes mellitus.Am J Health Syst pharm 2005;62:173-181.
  • 7Buse JB,Henry RR,Han J,et al.Effects of exenatide(exendin-4)on glycemic control over 30 weeks in sulfonylurea-treated pa-tients with type 2 diabetes.Diabetes Care 2004;27:2628-2635.
  • 8Holst JJ,Gromada J. Role of inrcretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans[J].American Journal of Physiology Endocrinology and Metabolism,2004,(02):199-206.
  • 9Deacon CF. Therapeutic strategies based on glucagon-like peptidel[J].Diabetes,2004,(09):2181-2189.
  • 10Sinclair E M,Drucker D J. Proglucagon-derived Peptides:Mechanisms of Action and Therapeutic Potential[J].Physiology(Bethesda),2005.357-365.

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国际内科学杂志
2008年 第12期

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