血浆溶血磷脂酸水平与卵巢癌的关系

The Relationship of Plasma LysopHospHatidic Acid and Ovarian Tumor.

目的探讨血浆溶血磷脂酸(LPA)水平的测定在卵巢癌患者诊断中的价值。方法用生物化学方法测定卵巢癌患者30例、卵巢良性肿瘤患者28例及20例健康妇女的血浆LPA水平,同时测定卵巢癌患者血浆CA125含量,并作对比分析。结果卵巢癌患者血浆LPA水平明显高于卵巢良性肿瘤患者及健康妇女(P<0.05),后两者血浆LPA水平无统计学意义;血浆LPA和CA125对卵巢癌诊断的敏感性和特异性分别为90%、85.7%和66.7%、78.6%。结论血浆LPA水平在卵巢癌患者中升高,与CA125相比更具有临床价值,有望成为新的检测卵巢癌的标志物。

Objective To study the level of plasma lysopHospHatidic acid（LPA） in ovarian tumor paitents. Methods The level of plasma LPA was detected by LPA biochemistry kit in patients with malignant ovarian tumor（30cases）, begin ovarian tumor（ 28 cases ） and normal woman （ 20 cases）. The plasma CA125 levels were measured from patients with ovarian tumor at the same time. Results Plasma LPA level in patients with ovarian tumor was signicantly higher than that in the patients with begin ovarian tumor and normal women （ P 〈 0. 05 ） . While there was not a distinctive difference. The sensitivity and specificity of plasma LPA for ovarian tumor were 90% and 85.7%. Where as the sensitivity and specificity of CA125 were 66.7% and 78. 6%. Conclusion Plasma LPA level in patients with ovarian tumor was significantly increased. LPA may be a potential biology maker of ovarian tumor.