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乳腺癌中c-erbB-2和p53联合表达与癌细胞浸润转移关系的研究

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摘要 目的:研究乳腺癌组织中c-erbB-2和p53蛋白的表达,并探讨其联合表达与乳腺癌浸润转移的关系。方法:采用免疫组织化学方法,观察82例乳腺癌组织中c-erbB-2和p53蛋白的表达。结果:乳腺癌组织中c-erbB-2和p53蛋白的表达率分别为53.7%和68.3%;c-erbB-2和p53蛋白的表达均与乳腺癌淋巴结转移有关(P<0.05),c-erbB-2的表达还与乳腺癌浸润程度有关(P<0.05);c-erbB-2(+)和p53(+)组合的淋巴结转移率为75.0%,明显高于其他组合(P<0.01)。结论:c-erbB-2和p53联合阳性表达可有效判断乳腺癌患者淋巴结转移。
出处 《中国社区医师(医学专业)》 2008年第24期170-170,共1页
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