板材市场从业人员血清脂质过氧化指标的观察

Observation on the Indexes of Lipid Peroxidation in Serum of Employees in Decoration Material Markets

目的研究板材市场空气中主要污染物浓度及其对板材市场从业人员血清中SOD、GSH-Px活力和MDA含量的影响。方法选取板材市场从事销售工作的20～30岁男性作为暴露组,共50例;选取在周围综合市场工作的相同年龄段的男性保安人员作为对照组,共58例。采用调查问卷了解板材市场工作人员的一般情况。按照试剂盒说明检测研究对象血清中SOD、GSH-Px活力及MDA含量。监测板材市场和综合市场空气中甲醛及苯系物的浓度。结果研究现场空气中甲醛、苯、甲苯、二甲苯浓度均未超过国家标准。暴露组和对照组现场空气中苯浓度的差异无统计学意义(P>0.05)。暴露组甲醛、甲苯、二甲苯浓度高于对照组,差异有统计学意义(P<0.05)。暴露组的SOD、GSH-Px活力及MDA含量均高于对照组,差异有统计学意义(P<0.05)。结论在低浓度甲醛、苯、甲苯、二甲苯暴露下,机体的SOD、GSH-Px活力可能会出现与职业暴露时不同的改变,这种变化可能验证了低浓度污染物暴露情况下的hormesis效应。

Objective To investigate the sort and the concentration of the dominant pollutants in the decoration material markets and to know the change of SOD, GSH-Px, MDA in the serum of employees. Methods 50 male employees were selected as the study group, 58 men who work in general markets were selected as the control group, aged 20-30 years. The basic information was collected by questionnaire, the concentration of formaldehyde and benzene homologues was determined by spectrophotometry and thermal desorption/gas chromatography, the activity of SOD, GSH-Px and the concentration of MDA in the serum was determined with regent kits. Results The dominant pollutants were formaldehyde, benzene, toluene and xylene. The concentrations of all pollutants were below the limits of Indoor Air Quality Standard. There were significant differences in pollutant concentrations, except benzene, between the decoration material markets and the general markets. The activity of SOD and GSH-Px and the concentration of MDA in the study group were significantly higher than those in the control group. Conclusion At low exposure of the investigated pollutants, the change of activity of SOD and GSH-Px and the concentration of MDA may be not the same as occupational exposure, and this will prove and explain the hormesis induced by low level exposure to pollutants.