病毒感染蛋白质组学研究进展

Advances in Viral Infection Proteomics

病毒的侵入会导致宿主细胞蛋白表达模式的改变,这种改变将影响宿主细胞的正常生理功能并决定病毒的致病进程和结果。因此,病毒感染蛋白质组学研究有助于揭示病毒与宿主的相互作用机制和病毒的分子致病机制,以及寻找病毒早期感染的分子标记、建立早期诊断方法、评价治疗效果和预后。本文介绍了病毒感染蛋白质组学研究技术、病毒诱导宿主细胞蛋白质组改变和病毒感染宿主血清差异蛋白质组等方面的研究进展。

Viral invasion will modify the pattems of host cell protein expression, which may affect the normal physiological function of host cell and determines viral pathogenic progress and consequence. Therefor, studies on viral infections proteomics contributes to uncover the mechanism of interaction between virus and host and viral molecular pathogenesis, found early biomarker of virus infection, develop earlier diagnostic method, evaluate therapeutic effect and prognosis and so on. In this paper, techniques of viral infection proteomics, the progress of changes of host cell proteome induced by virus, and serum differential proteome of host after viral infection were introduced.