浙江丽水地区2002～2007年医院感染真菌耐药性分析

Analysis of fungal resistance of hospital infection from 2002 to 2007 in Lishui

目的了解丽水市中心医院临床真菌分离株耐药性，为真菌感染的诊治提供依据。方法用ATB-Fungus试剂盒对2002年1月～2007年12月临床真菌分离株进行药敏试验。结果在2175株临床分离真菌中，白色念珠菌为81．1％，热带念珠菌为10．3％，近平滑念珠菌为2．6％，烟曲菌为2．5％，其余均在1％以下；白色念珠菌、热带念珠菌对两性霉素B和制霉菌素的耐药率较低，均在5％以下，2007年伏立康唑耐药率在0．5％以下，而5-氟胞嘧啶则逐年上升，耐药菌种逐渐增多。结论本地区真菌检出种数和检出率呈逐年上升趋势，两性霉素B和制霉菌素为有效的抗真菌药物。

Objective To investigate the resistance of fungi isolated from Lishui Central Hospital, provide evidence for diagnosis and treatment of fungi infection. Methods Fungal sensitive tests of clinical isolated strain were taken by ATB-Fungus method. Results Of 2175 fungi, 1765 （81.1%） were Candida albicans ,224 （ 10.3% ） were Candida tropicalis ,57 （2.6%） were Candida parapsilosis and 55 （2.5%） were Aspergillus fumigatus. Lung fungal infection is predominant. The resistant rates of Candida albicans and Candida tropicalls kept lower under 5% for Amphotericin B and Nystatin. The resistant rate of Voriconazole was less than 0.5% , But that of 5-fluorocytosine increased every year. The strains of multiple resistance,the detection rate and the strains all increased from 2002 to 2007. Conclusion The fungi detection sum and rate increase year by year in this area, Amphotericin B and Nystatin are effective antifungal agents.