促炎症消退介质脂氧素与炎症性疾病

Pro-resolving lipoxins and inflammatory diseases

脂氧素是炎症过程中产生的具有特征性三羟四烯结构的花生四烯酸衍生物,因具有独特的促炎症消退功效而成为目前炎症研究和新药开发的焦点。越来越多的研究证实,脂氧素代谢及效应的异常与临床多种炎症相关性疾病的发生发展关系密切。目前认为炎症自限机制发生障碍才是炎症失控的根本原因,而"促炎症消退"成为炎症治疗的新策略。

Lipoxins are trihydroxytetraene-containing arachidonic acid derivates generated during various inflammatory processes. Due to their unique anti-inflammatory properties, lipoxins have emerged to be the central targets in the research of inflammation and the development of novel anti-inflammatory drugs. More and more evidences have revealed that the aberrant metabolisms and functions of lipoxins are closely related to the pathogenesis of inflammation-based diseases. At present, the uncontrolled inflammation has been considered as the results of the failed resolution of inflammatory response, and promoting the resolution of inflammation has become the novel therapeutic strategy against numerous inflammatory diseases.