低氧对视动刺激诱发的运动病的影响(英文)

Effect of Hypoxia on Motion Sickness Induced by Optokinetic Stimulation

为探讨中度低氧对视动刺激诱发运动病的影响及其特点和规律，２０名１８～２５岁的健康男性，按照“拉丁方”排列和“自身对照”法，进行了单纯视动刺激和低氧视动刺激试验。主要观察和记录了运动病症状及视动性水平眼震（ＯＫＨＮ）。结果显示：（１）低氧视动刺激（ＨＯＳ）的运动病症状得分显著高于单纯视动刺激（ＯＳ）时的得分（Ｐ＜０．００１）；（２）低氧视动刺激时的视动性水平眼震慢相速度（ＳＰＶ）显著小于单纯视动刺激时（Ｐ＜０．００１）。这证明中度低氧能加重视动刺激诱发的运动病。此结果为航天运动病易感性的筛选提供了一个新的思路。

The purpose of this experiment was to study the effect of hypoxia on motion sickness (MS) induced by optokinetic stimulation and to observe its character and principle. Twenty healthy male subjects aged 18～25 years received optokinetic stimulus (OS) and hypoxic-optokinetic stimulus(HOS) according to the “Latin Square” arrangement and “Self-control” methods .Motion sickness symptoms (MSS) and optokinetic horizontal nystagmus(OKHN)were recorded and analysed. The results indicated :(1)MS average score for HOS was higher than that for OS (P<0.001);(2) Slow phase velocity(SPV) of OKHN in HOS was lower than that in OS (P<0.001).The results clearly showed that moderate hypoxia could deteriorate the MS induced by OS. It provided a method for the screening of MS sensitivity. 