芹菜籽提取物对高尿酸血症大鼠的影响

Effect of Celery Seed Extract on Hyperuricemia in Rats

目的:研究芹菜籽提取物对于高尿酸血症大鼠血清尿酸水平的影响及对于急性痛风性关节炎的抗炎镇痛效果。方法:将50只Wistar雄性大鼠分为阴性对照组、模型对照组、芹菜籽提取物低、中、高剂量组。用酵母+腺嘌呤法致大鼠高尿酸血症,在造模的同时,给予上述药物灌胃,6w后检测各组大鼠血清尿酸(UA)、尿素氮(BUN)、肌酐(Cr)和肝脏黄嘌呤氧化酶活性等指标。肾脏进行病理检查。尿酸钠晶体致大鼠足跖肿胀,观察芹菜籽提取物抗炎作用。结果:高剂量组芹菜籽提取物可以降低高尿酸血症大鼠血清中尿酸的含量,差异有统计学意义(p<0.05)。中、高剂量组的黄嘌呤氧化酶活性低于模型对照组,但无统计学差异(p>0.05)。高剂量组足肿胀率明显低于模型对照组,差异具有统计学意义(p<0.05)。各剂量组肾脏病理改变轻于模型对照组。结论:提示芹菜籽提取物对于高尿酸血症及其引起的肾功能损害有一定的保护作用。

Objective： To study the effect of celery seed extract on the leve of uric acid in rats with hyperuricemia and the control of joint inflamation in gouty arthritis. Methods： Uric acid nephropathy rats models were established by feeding yeast and adenine. Fifty male Wistar rats were divided into five groups including control group, model group and celery seed extrac treatment groups （high-, moderate- and low-doses）. The serum uric acid （UA）, urea nitrogen （BUN）, creatinine （Cr） and activity of liver xanthine oxidase were measured and the pathological changes in renal were detected. The model of acute arthritis was induced by injecting monosodium urate （MSU） into unilateral ankle of rat. Results： The level of serum uric acid of the high-dose treatment group is significantly different from that of the model group （p 〈 0.05）. In the high and moderate-dose groups, the activity of the liver xanthine oxidase reduces, but there are no obvious difference between the model group and the two groups （p 〉0.05）. The swelling rate of the high-dose group is obviously lower than that of the model group （p 〈0.01）. The pathological changes in renal of all the treat ment groups are lower than that of the model group. Conclusion： The celery seed extrac has some protective effects on the hyperuricemia and the damage of kidney＇ function.