亚硒酸钠在低硒雏鸡体内组织药动学的研究

Study on the tissue pharmacokinetics of sodium selenite in the lowselenium Chicken

低硒雏鸡按单剂量0．526mg／kgBW口服亚硒酸钠后在不同时间点采集肝、肾、胰、心、肺、脾、十二指肠和胸肌，用荧光分光光度法测定组织硒浓度。应用微机MCPKP药动学程序自动拟合组织硒浓度－时间数据并求药动学参数。结果显示，心、肺、十二指肠符合一定开放模型，肝、肾、脾、胰符合二室开放摸型，肌肉符合吸收滞后二室开放模型。吸收以肝、十二指肠为最快，肾、胰、心、肺、脾依次减慢，肌肉吸收最慢，并有一个滞后期。组织中硒的消除均较缓慢。

A single of sodium selenite (0. 526 mg/kg BW)were given to low-selenium chicken through mouth. Selenium in issues were determined by,using the fluoreecence method procedure. The results showed that: lungheart and duodenum conformed the one-compartment open model ;liver,kidney,spleen and pancrea conformed the tow-compartment open model. Theabsorption of selenium in tissues liver and doudenum were the est,kidney,pancrea,heart,lung and spleen were in order of becoming slower,mucle was the slowest and with a lagtime.The elimination of seleniumin tissues was all slow.