胶质细胞源性神经生长因子与慢传输性便秘

Glial cell line-derived neurotrophic factor and slow transit constipation

慢传输型便秘(STC)至今病因未明。肠神经系统(ENS)可独立调节肠道功能,其在慢传输型便秘中的改变具有重要意义。胶质细胞源性神经营养因子(GDNF)不仅可促进多种神经元的存活与分化,而且对多种原因造成的神经损伤具有明显的保护作用。此文主要从肠神经系统的功能变化和胶质细胞源性神经营养因子的营养作用这两方面来阐述与功能性便秘之间的相关性。

Slow transit constipation＇s（STC）etiopathogenisis is not clearly. Enteric nervous system （ENS）is able to independently regulate bowel function and its changes in the slow transit constipation is of great significance. Glial cell line derived neurotrophic factor not only promotes the survival and differentiation of various neural neurons, but also protects neural injuries caused by a variety of reasons. This review will elaborate the relationship between psychological state and level of activity of en teric nerve system in patients with slow transit constipation.