中药制剂伤肌宁治疗病毒性心肌炎的临床观察

Clinical Study on Effect of Traditional Chinese Preparation-Shangji-ning Granule for Treatment of Viral Myocarditis

目的观察中药制剂伤肌宁治疗病毒性心肌炎的治疗效果。方法共入组病毒性心肌炎患者60例,其中试验组30例,对照组30例。分别为常规西药对照组,常规西药+口服伤肌宁颗粒治疗组,伤肌宁颗粒口服一日三次,疗程均为4周。采用临床症状指标包括心悸,胸闷,胸痛,气短和乏力等评定疗效;用病毒中和抗体滴度的变化评价药物的抗病毒能力。结果①伤肌宁组总有效率为96.67%,高于对照常规西药组的60.00%(P<0.01)。②伤肌宁组与对照组的各项临床症状包括心悸,胸闷,胸痛,气短和乏力等均较治疗前有所改善,治疗后病毒中和抗体的滴度(柯萨奇B组病毒1、2、3、4、5,A组9型,艾柯病毒6、9型)均有明显下降,并且,伤肌宁制剂组对临床症状的改善程度和降低各种病毒中和抗体的效应方面均强于对照组。结论中药制剂伤肌宁能够通过抑制病毒感染,改善心功能等作用,有效的治疗病毒性心肌炎疾病。

Objective To observe the efficacy of Chinese traditional preparation Shangji-ning granule for treatment of viral myocarditis. Methods 60 patients with viral myocarditis were enrolled in a randomized, parallel controlled study. The patients in control group were treated with routine western medicine, for 4 weeks, while the patients in treatment group, on the basis of routine therapy, were treated with Shangji-ning granule once,3 times a day,and the clinical efficacy were observed. Clinical symptoms （palpitation,chest distress,chest pain,shortness of breath and hypodynamia） were used to evaluate the efficacy. The various neutralization viral antibody titers were used to assess the ability of the antivirus action. Results ①The total remission rates of Shangji-ning granule was 96.67% ,which was obviously higher than that in the control group with 60.00% （P 〈0.01）.②The main clinical symptoms：palpitation,chest distress,chest pain,shortness of breath and hypodynamia improved more significantly in treatment group than in control group. Compared with control group,the level of various neutralization viral antibody titer including coxsakie viral B （CVB1-5）, oxsakie viral B （CVA9） in Shangji-ning group have largely decreased. The total effect of the Shangji-ning group was the best. Conclusion The Chinese traditional preparation Shangji-ning granule tested in this study can treat viral myocarditis through inhibiting virus directly and improving Cardiac Function.