血管内皮生长因子在老年OSAHS患者高血压形成中的作用

Role of Vascular Endothelial Growth Factor in the Pathogenic Mechanisms in Elderly Patients with Obstructive Sleep Apnea -hypopnea Syndrome Accompanied by Hypertension

目的探讨血管内皮生长因子在老年阻塞性睡眠呼吸暂停低通气综合征患者高血压形成中的作用。方法检测并分析比较OSAHS合并高血压患者与单纯OSAHS患者的血浆VEGF水平。结果(1)OSAHS合并高血压组的血浆VEGF浓度显著高于单纯OSAHS组(P<0.01)。(2)高血压水平与血浆VEGF浓度(r=0.602,P=0.016)呈正相关。结论血管内皮生长因子在OSAHS合并高血压的形成发展过程中发挥重要的促进作用。

Objective To investigate the role of vascular endothelial growth factor in the pathogenic mechanisms in elderly patients with obstructive sleep apnea-hypopnea syndrome accompanied by hypertension. Methods The 40 patients diagnosed OSAHS by Polysomnography were divided into OSAHS with hypertension group and OSAHS without hypertension group, and the level of plasma vascular endothelial growth factor were analysised and compared. Results The research showed：①The levels of plasma VEGF were significantly higher in OSAHS with hypertension group than those in OSAHS without hypertension group （P〈 0.01 ）. ②There were positive correlations between hypertension and the levels of plasma VEGF（r = 0.602, P = 0.016）. Conclusion VEGF plays an important role in the pathogenic mechanisms of hyperte -nsion in obstructive sleep apnea-hypopnea syndrome.