代谢综合征发病机制研究进展

Advance on the Pathogenesis of Metabolic Syndrome

随着经济的发展和人们生活水平的提高以及生活方式的改变,代谢综合征(metabolic syndrome,MS)的患病率逐年上升。代谢综合征是一种涉及多种代谢异常、与心血管病紧密联系的疾病状态。肥胖或超重、糖调节异常或糖尿病、高血压和高血脂是MS的重要组成元素。代谢综合征一直是人们关注的热点,但截止目前确切机制仍不明确。主要围绕肥胖与胰岛素抵抗展开研究,特别是在脂毒性和脂肪分泌因子的调控以及各种炎性因子的影响方面取得了一些进展。

A prevalence of Metabolic Syndrome （MS） has been increasing recently when our economy is bursting and the change of lifestyle. MS may manifest as so many metabolic abnormalities, such as obesity,hypertension and hyperlipidemia and so on. Obesity, overweight,poor glucose regulation, even diabetes which are believed to be the main components of MS. MS has been still a hot point in metabolic diseases, however, the exact pathogenesis still remains unclear by now. Present studies of MS mainly focus on obesity, insulin resistance, lipid toxicity, regulation of adipose cytokine and various inflammatory reaction profiles. Some of the studies have got a significant advance on it.