三氧化二砷治疗22例复发性急性早幼粒细胞白血病疗效观察

The observation of curative effect of recurrent acute premyelocytic leukemia with arsenic trioxide in 22 cases

目的:探讨三氧化二砷在治疗复发性急性早幼粒细胞白血病的临床疗效及安全性。方法:采用三氧化二砷(As2O3)治疗22例复发性急性早幼粒细胞白血病患者。每日予以三氧化二砷10ml+5%葡萄糖溶液静脉滴注,每日1次,每次3～4h,连用28d,同时予以肝功能及心电图监测。结果:完全缓解16例,部分缓解2例,未缓解4例,有效率为81%。在治疗过程中,出现一过性转氨酶升高4例,频发室性早搏4例,心电图ST-T动态明显改变2例。未停止化疗,予以保肝、营养心肌治疗后不良反应消失。结论:三氧化二砷是目前治疗复发性急性早幼粒细胞白血病的有效药物。

Objective： To investigate clinical outcome and safety factor of recurrent acute premyelocytic leukemia with arsenic trioxide. Methods： 22 cases of recurrent acute premyelocytic leukemia were treated with arsenic trioxide. Daily arsenic trioxide to 10 ml＋5% glucose infusion, once daily, every 3-4 hours, for 28 days. In the course of treatment, electrocardiogram and liver function were inflicted upon monitoring. Results： 16 cases were complete remission, 2 cases were partial remission, 4 patients were no remission, so the total effective rate was 81%. During the therapeutic schedule, The transient rise of ALT occurred in 4 cases, and frequent ventricutar premature beat in 4 patients. 2 patients had dynamic distinct change in ST-T of ECG. Chemotherapy did not stop, to the liver, nutrition and cardiac side effects disappeared after treatment. Conclusion： Arsenic trioxide is currently an effective method in the treatment of acute premyelocytic leukemia.