影响HBV宫内感染的相关临床因素的探讨

Associative clinical study on hepatitis B virus intrauterine infection

目的探讨乙型肝炎病毒(HBV)宫内感染的高危因素或保护因素。方法对2006年6月至2008年2月在中山大学附属第三医院产科分娩的417例血清HBsAg阳性孕妇的新生儿进行回顾性分析。结果HBV宫内感染组33例,非感染组384例,感染组的母亲HBeAg阳性率、HBV DNA阳性率和非感染组的具有显著性差异(P<0.05),母亲孕晚期注射HBIG在2组中均无显著性差异(P>0.05);在母亲各HBV DNA水平级上分析,新生儿HBV宫内感染和母亲使用HBIG均无明显相关(P>0.05);结论1.HBV DNA阳性是HBV宫内感染的高危因素。2.HBsAg阳性孕妇晚孕期间肌注HBIG对HBV宫内感染未见明显的保护作用。

Objective： To explore the risk factors or protective factors of Hepatitis B virus （HBV） intrauterine infection. Methods： 417 newborns born to HBsAg - positive mothers delivered in Obstetric department of the Third Affiliated Hospital of Sun Yat - Sen University from June 2006 to February 2008 were analyzed retrospectively. Results ： The difference of maternal use of HBIG during pregnancy between the HBV intrauterine infection group and non - infected group was not statistically significant （ P 〉 0. 05 ）. Maternal HBeAg positive rate and maternal HBV DNA positive rate between the two groups were found statistically significantly different （ P 〈 0.05 ）. Conclusions ： 1. HBV DNA level is the independent risk factor for HBV intrauterine infection ; 2. Maternal administration of HBIG in third trimester of pregnancy has not yet proved to be a protective factor for HBV intrauterine infection according to this research.