注射用盐酸头孢甲肟治疗急性细菌感染的临床评价

Clinical Evaluation of Injectable Cefmenoxime Hydrochloride in the Treatment of Acute Bacterial Infection

目的：考察注射用盐酸头孢甲肟治疗急性细菌感染的临床疗效、细菌学疗效和安全性。方法：将126名入选患者随机分为两组：试验组（n=62）和对照组（n=64），分别接受同剂量注射用盐酸头孢甲肟和头孢噻肟钠静脉滴注治疗（2g，bid），疗程为7—14d。结果：试验组和对照组的临床痊愈率分别为74．19％和68．75％（P=0．8844），有效率分别为95．16％和95．31％（P=0．9020），均无显著差异；两组细菌清除率分别为90．57％和86．54％（P〉0．05），无显著差异；两组不良反应发生率分别为1．61％和4．69％（P〉0．05），无显著差异，且不良反应大多轻微并为一过性。结论：注射用盐酸头孢甲肟可安全、有效地用于治疗急性细菌感染。

Objective： To evaluate the clinical efficacy, bacteriological efficacy and safety of injectable cefmenoxime hydrochloride in the treatment of acute bacterial infection. Methods： 126 Recruited patients were divided at random into two groups： treatment group （62 cases） and control group （64 cases）, who received injectable cefmenoxime hydrochloride in treatment group or cefotaxime sodium in control group （2 g, iv gtt, bid） for 7 - 14 d. Results： There were no significant differences in curative rate（74.19% vs 68.75%, P = 0. 884 4）, effective rate（95. 16% vs 95.31%, P = 0. 902 0）, bacterical clearance rate （90. 57% vs 86.54%, P 〉0.05） and incidence of side effects（ 1.61% vs 4.69%, P 〉 0.05） between treatment group and control group. These side effects were mild and transient in the trial. Conclusion： Injectable cefmenoxime hydrochloride is a safe and effective agent for treatment of acute bacterial infection.