联用灯盏细辛与弥可保治疗糖尿病周围神经病的疗效

Curative Effectiveness of Erigeron Breviscapus Combined with Mexobalamin in the Treatment of Diabetic Peripheral Neuropathy

目的:探讨灯盏细辛与弥可保联合应用对糖尿病周围神经病变(DPN)的疗效。方法:106例DPN患者随机分为2组各53例,在常规口服降糖药或胰岛素治疗基础上,2组均采用弥可保注射液500μg静脉推注,每日1次。观察组同时加用灯盏细辛注射液30ml于生理盐水250ml中静脉滴注。结果:与治疗前比较,2组患者治疗4周后血糖均明显下降(P<0.05),血脂、尿微量白蛋白排泄率、纤维蛋白原观察组明显改善,对照组无显著变化;神经传导速度在治疗4及6周时2组均缓慢上升,观察组上升速度明显快于对照组。临床疗效比较,观察组总有效率明显高于对照组(83.0%与52.8%,P<0.01)。结论:灯盏细辛与弥可保联合应用治疗DPN可显著改善患者临床症状,提高疗效。

Objective：To discuss the curative effectiveness of erigeron breviscapus combined with mexobalamin in the treatment of diabetic peripheral neuropathy. Methods： 106 patients with diabetes were randomly divided into two groups with 53 patients in each group. The patients in two groups were all treated with hypogtycemic drugs or insulin. The patients in the erigeron breviscapus and mexobalamin group were treated with erigeron breviscapus （50 mg） and mexobalamin （500μg） combined, once a day, and those in the control group were treated with mexobalamin （500μg） alone, daily once. The treatment courses were 4 weeks. Results：The effective rate in the erigeron breviscapus and mexobalamin group was 83%after 4 weeks and 84.9% after 6 weeks respectively, and the improvement degree of nerve conduction speed was significantly better than that in control group （P〈0.01）. Conclusion： Erigeron breviscapus combined with mexobalamin to treat diabetic peripheral neuropathy is an effective therapy.