SUMO化修饰对NF-κB信号通路的调控

SUMOylation Regulating NF-κB Signaling Pathway

小泛素相关修饰物(small ubiquitin-related modifier,SUMO)经由一系列酶介导的生化级联反应共价结合于靶蛋白的赖氨酸残基上,稳定靶蛋白免受降解的过程称为SUMO化修饰(SUMOylation)。核转录因子κB(nuclear factors κB,NF-κB)是公认的炎症和免疫反应的重要调节因子,并与糖尿病的发生发展密切相关。近年来研究发现,不仅NF-κB抑制蛋白(inhibitor of NF-κB,IκB)的SUMO化修饰参与NF-κB信号通路的调节,而且SUMO酶可以直接调节NF-κB对靶基因的转录。现就SUMO亚型及结构,SUMO化修饰与去SUMO化修饰过程,SUMO、SUMO酶对NF-κB的转录调控及其与糖尿病相关性的最新研究进展作以综述。

We intitule the progress that the small ubiquitin-related modifier （SUMO） covalently attaches to lysine residues of target proteins, through a series of SUMO enzymes-mediated biochemical cascades, to stabilize them from degradation as SUMOylation. Nuclear factor κB （NF-κB） has been well known as a regulator participating in inflammation and immunity reactions, and it also gets close related to the source and development of diabetes. According to the investigation these years, not only SUMOylation of the inhibitor of NF-κB （κB） takes participate in the regulation of NF-κB signaling pathway, but also the SUMO enzymes can directly regulate transcriptions of the NF-κB target genes. Now we will summarize as below： the current investigation about the subtype and structure of SUMO, the processes of SUMOylation and desumoylation, the regulations of SUMO and its enzymes on NF-κB signaling pathway and their correlations with diabetes.